Cichorium intybus L. promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia

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Cichorium intybus L. promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia

BACKGROUND Excessive production and/or reduced excretion of uric acid could lead to hyperuricemia, which could be a major cause of disability. Hyperuricemia has received increasing attention in the last few decades due to its global prevalence. Cichorium intybus L., commonly known as chicory, is a perennial herb of the asteraceae family. It was previously shown to exert potent hypouricemic effe...

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Relationship between High-Performance Liquid Chromatography Fingerprints and Uric Acid-Lowering Activities of Cichorium intybus L.

This study aimed to explore the spectrum-effect relationships between high-performance liquid chromatography fingerprints and the uric acid-lowering activities of chicory. Chemical fingerprints of chicory samples from ten different sources were determined by high-performance liquid chromatography, and then investigated by similarity analysis and hierarchical clustering analysis. Pharmacodynamic...

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Red Chicory (Cichorium intybus L. cultivar) as a Potential Source of Antioxidant Anthocyanins for Intestinal Health

Fruit- and vegetable-derived foods have become a very significant source of nutraceutical phytochemicals. Among vegetables, red chicory (Cichorium Intybus L. cultivar) has gained attention for its content of phenolic compounds, such as the anthocyanins. In this study, we evaluated the nutraceutical effects, in terms of antioxidant, cytoprotective, and antiproliferative activities, of extracts o...

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PHYTOCHEMICAL INVESTIGATION AND ANTIMICROBIAL ACTIVITY OF Cichorium intybus L

Plants have basic nutritional importance by their content of protein, carbohydrate, fats and oils minerals, vitamins and water responsible for growth and development in man and animals. Phytochemical simply means plant chemicals. Phytol is the Greek word for plant. Phytochemicals are classified as primary or secondary constituents, depending on their role in plant metabolism. Primary metabolism...

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Phytochemical and Biological Evaluation of Cichorium intybus L. Seeds

In this study, we aim to demonstrate, separately, the hepatoprotective activity of the total ethanolic extract as well as the defatted ethanolic extract of Cichorium intybus L., using adult Wister albino rats (120-170 g) as the experimental animals. The total as well as the defatted alcoholic extracts of Cichorium intybus L., seeds possess significant hepatoprotective activity; which may be att...

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ژورنال

عنوان ژورنال: Nutrition & Metabolism

سال: 2017

ISSN: 1743-7075

DOI: 10.1186/s12986-017-0190-6